Gardasil 9 (Human Papillomavirus 9-valent Vaccine, Recombinant) 0.5 mL SDV

 Physician's authorization is required to purchase this item.

Indication for Gardasil 9
Gardasil 9 is a vaccine indicated in females 9 through 26 years of age for the prevention of cervical, vulvar, vaginal, and anal cancers caused by human papillomavirus (HPV) Types 16, 18, 31, 33, 45, 52, and 58; precancerous or dysplastic lesions caused by HPV Types 6, 11, 16, 18, 31, 33, 45, 52, and 58; and genital warts caused by HPV Types 6 and 11.

Gardasil 9 is indicated in males 9 through 26 years of age for the prevention of anal cancer caused by HPV Types 16, 18, 31, 33, 45, 52, and 58; precancerous or dysplastic lesions caused by HPV Types 6, 11, 16, 18, 31, 33, 45, 52, and 58; and genital warts caused by HPV Types 6 and 11.

Gardasil 9 (Human Papillomavirus 9-valent Vaccine, Recombinant) does not eliminate the necessity for girls to continue to undergo recommended cervical cancer screening later in life. Recipients of Gardasil 9 should not discontinue anal cancer screening if it has been recommended by a health care professional.

Gardasil 9 has not been demonstrated to provide protection against diseases from vaccine HPV types to which a person has previously been exposed through sexual activity.

Gardasil 9 is not a treatment for external genital lesions; cervical, vulvar, vaginal, and anal cancers; or cervical intraepithelial neoplasia (CIN), vulvar intraepithelial neoplasia (VIN), vaginal intraepithelial neoplasia (VaIN), or anal intraepithelial neoplasia (AIN).

Not all vulvar, vaginal, and anal cancers are caused by HPV, and Gardasil 9 protects only against those vulvar, vaginal, and anal cancers caused by HPV Types 16, 18, 31, 33, 45, 52, and 58.

Vaccination with Gardasil 9 may not result in protection in all vaccine recipients.

Select Safety Information for Gardasil 9

Gardasil 9 is contraindicated in individuals with hypersensitivity, including severe allergic reactions to yeast, or after a previous dose of Gardasil 9 or Gardasil [Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) Vaccine, Recombinant].

Because vaccinees may develop syncope, sometimes resulting in falling with injury, observation for 15 minutes after administration is recommended. Syncope, sometimes associated with tonic-clonic movements and other seizure-like activity, has been reported following HPV vaccination. When syncope is associated with tonic-clonic movements, the activity is usually transient and typically responds to restoring cerebral perfusion.

Safety and effectiveness of Gardasil 9 have not been established in pregnant women.

The most common (≥10%) local and systemic adverse reactions in females were injection-site pain, swelling, erythema, and headache. The most common (≥10%) local and systemic reactions in males were injection-site pain, swelling, and erythema.

The duration of immunity of Gardasil 9 has not been established.

Dosage and Administration for Gardasil 9

Gardasil 9 should be administered intramuscularly in the deltoid region of the upper arm or in the higher anterolateral area of the thigh.

For individuals 9 through 14 years of age, Gardasil 9 can be administered using a 2-dose or 3-dose schedule. For the 2-dose schedule, the second dose should be administered 6–12 months after the first dose. If the second dose is administered less than 5 months after the first dose, a third dose should be given at least 4 months after the second dose. For the 3-dose schedule, Gardasil 9 should be administered at 0, 2 months, and 6 months.
For individuals 15 through 26 years of age, Gardasil 9 is administered using a 3-dose schedule at 0, 2 months, and 6 months.