Inhibits bacterial protein and RNA synthesis by reversibly and specifically binding to bacterial isoleucyl-transfer RNA synthetase. Bactericidal.
Intranasal ointment: 2.15%
Topical cream: 2%
Topical ointment: 2%
Indications and dosages:Impetigo
Adults and children ages 2 months to 16 years: Apply a small amount of ointment topically t.i.d. for 3 to 5 days. Reevaluate if no response.
Infected traumatic skin lesions
Adults and children ages 3 months to 16 years: Apply a small amount of cream topically t.i.d. for 10 days.
Nasal colonization of methicillin-resistant Streptococcus aureus
Adults and children ages 12 and older: Apply intranasal ointment (half of single-use tube to each nostril) topically to anterior nares b.i.d. for 5 days.
Hypersensitivity to drug or its components
Use cautiously in:
moderate or severe renal impairment (with large doses)
children younger than age 12 (intranasal ointmment), younger than age 3 months (cream), or younger than age 2 months (ointment).
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