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Methotrexate (formerly Amethopterin) is an antimetabolite used in the treatment of certain neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis.
Methotrexate Injection, USP is sterile and non-pyrogenic and may be given by the intramuscular, intravenous or intra-arterial route. However, the preserved formulation contains Benzyl Alcohol and must not be used for intrathecal or high-dose therapy.
Each mL contains methotrexate sodium equivalent to 25 mg methotrexate, Preservative: Benzyl Alcohol 0.9% w/v, and the following inactive ingredients: Sodium Chloride 0.26% w/v and Water or Injection qs ad 100% v. Sodium Hydroxide and/or Hydrochloric Acid may be added to adjust the pH to approximately 8.5.